.popupbutton
Opting for the class will result in quicker performance. However, the time saved is minimal, around 20-50ms, which may or may not be significant depending on the context.
A comprehensive test comparing CSS selector speeds across various browsers can be found here:
On average, there is a 50ms slowdown across all browsers, and for major ones like IE 6 & 7, FF3, the average difference is just 20ms. Enhancing CSS selectors would only bring about a 20ms improvement for 70% or more of current users.
As demonstrated in the article, the variance in selector speed is minimal even in tests involving complex DOM scenarios.