I recently heard that some designs do not support grid system layouts like Bootstrap or Foundation. This has left me unsure about what elements to analyze in a design before starting work on it. I know Bootstrap uses a 12-column grid system, but I am uncertain about how to properly analyze a design. For example, attached is an image of a web design - can anyone explain to me how I should go about analyzing this before diving in? Additionally, the client wants the design to be 1600px on large view. Link to image