On my Macbook Pro running Mojave, I noticed that regular fonts appear normal, but large fonts look jagged in Chrome (unlike Safari or Firefox).
You can see an example on CodePen
.large {
font-size: 300px;
font-weight: bold;
}
Chrome
https://i.sstatic.net/kT3mY.png
Safari
https://i.sstatic.net/UQvzS.png
Firefox
https://i.sstatic.net/xkgTP.png
Despite trying the suggestions from this Stack Overflow post (enabling font cache scaling and accelerated 2D Canvas), the issue persists.