There is an issue where click events are sometimes not triggered when an element contains another element being animated with CSS transitions.
To see an example of this problem, check out the test case at http://codepen.io/anon/pen/gbosy
In my layout, I have a set of images with captions that appear on hover and slide down an adjacent element when clicked. Users tend to quickly click through these elements. The problem is more prominent on the live site compared to the codepen example.
In the codepen, about 90% of my clicks register successfully, but when CSS transitions are disabled, all clicks work as expected.
If you have any suggestions or solutions, please share them.
It's worth mentioning that this issue is most noticeable in Chrome, less common in Safari, and even less so in Firefox.