Although I am aware of the Workspaces feature recently added to DevTools, it does not address my specific needs. For instance, when a page utilizes jQuery from a CDN and I make modifications to the library code, saving them by pressing ctrl-s only to find that the changes are lost upon reloading the page. Additionally, there are situations where I need to debug a site but do not have permission to alter any files.
My goal is not just to save changes like in saving CSS while browsing using Chrome Dev or Firebug, but rather to ensure that these modifications persist between page reloads.