When it comes to designing a website, there are various opinions on the best window size or viewport size to cater to. If you want to reach a wide audience, what size should you prioritize? For example, if you are creating a gaming website, should you assume that users will not have screens as small as 800x600?
Another question that arises is whether it is better to keep the main containing div at an auto size, allowing it to stretch with the screen size (unless there are fixed elements that should not stretch), or should you fix the width? Having designed several websites, I am still unsure of the best practices in 2012.